Adolf von Baeyer
(1835 – 1917)
On October 31, 1835, German chemist and Nobel Laureate Johann Friedrich Wilhelm Adolf von Baeyer was born. He was the first who succeeded with the synthesis of indigo (1880) and formulated its structure (1883), for which he was awarded the Nobel Prize for Chemistry in 1905.
Adolf von Baeyer – Academic Career
Adolf Baeyer was a son of the officer and geodesist Johann Jacob Baeyer and Eugenie Hitzig, daughter of the publisher and writer Julius Eduard Hitzig. Godparents were the writer Adelbert von Chamisso  and the astronomer Friedrich Wilhelm Bessel. Adolf von Baeyer was interested in chemical experiments from early age.After attending the Friedrich-Wilhelms-Gymnasium in Berlin, he first studied mathematics and physics at the Friedrich-Wilhelms-Universität Berlin, then chemistry with Robert Bunsen at the Ruprecht-Karls-Universität Heidelberg. He received his doctorate under the supervision of Friedrich Kekulé in 1858 with a dissertation De arsenici cum methylo conjunctionibus (On methylarsine compounds). In 1859, he became a private lecturer at the Friedrich Wilhelm University in Berlin, but followed Kekulé to Ghent for his further research. In 1860, Baeyer habilitated in Berlin and accepted a teaching position for organic chemistry at the Gewerbeinstitut in Berlin. [1,3]
The Discovery of Indigo
In 1860, Baeyer habilitated in Berlin and accepted a teaching position for organic chemistry at the Gewerbeinstitut in Berlin. In 1866, the University of Berlin, at the suggestion of A.W. Hofmann, conferred on him a senior lectureship, which, however, was unpaid. In this period however, Baeyer started his work on indigo, which soon led to the discovery of indole and to the partial synthesis of indigotin. Also in this period, Baeyer developed his theory of carbon-dioxide assimilation in formaldehyde. He was appointed chair at the University of Munich after Justus von Liebig had passed away and Baeyer was able to perform the synthesis of indigo. One year later, in 1881, the Royal Society of London awarded him the Davy Medal for his work with indigo. In 1883 Baeyer succeeded in correctly elucidating the structure of indigo. Although Baeyer patented the synthesis of indigo, it was not really economically feasible. The manufacturing costs were too high compared to the natural dye, so that this synthesis route had to be abandoned. Later, Baeyer and Viggo Beutner Drewsen developed an industrially insignificant indigo synthesis from nitrobenzaldehyde. Only in 1900 Karl Heumann developed an economical indigo synthesis.
The Synthesis of Alizarin
Another economically important natural dye at the time was alizarin, which Baeyer’s assistants Carl Graebe and Liebermann reduced to anthracene using zinc dust. They now developed a new anthraquinone synthesis from anthracene with potassium dichromate and sulfuric acid. By treating the anthraquinone with bromine at 100 °C and subsequent treatment with potassium hydroxide, the alizarin could also be synthesized. Baeyer and Carlo clarified the position of the hydroxy groups in alizarin. Baeyer also discovered the group of triphenylmethane dyes. To celebrate Baeyer’s 70th birthday, a collection of his scientific papers was published in 1905. [1,2]
Nobel Prize and Later Years
Also in 1905 he was awarded the Nobel Prize in Chemistry for his services to “the development of organic chemistry and the chemical industry through his work on organic dyes and hydroaromatic compounds”. Adolf von Baeyer‘s work was known to be completed with admirable penetration and extraordinary experimental skill. He was careful never to overestimate the value of a theory. While Kekulé sometimes approached Nature with preconceived opinions, von Baeyer would say: “I have never set up an experiment to see whether I was right, but to see how the materials behave“. Even in old age his views did not become fixed, and his mind remained open to new developments in chemical science. 
At yovisto academic video search, you may be interested in a short video on how to fabricate indigo.
References and Further Reading:
-  Adolf von Baeyer at Nobel Prize
-  Adolf von Baeyer at Britannica
-  Adolf von Baeyer at Famous Scientists
-  Justus von Liebig and the Agricultural Revolution, SciHi Blog
-  August Kekulé and the Carbon Ring Structure, SciHi Blog
-  The Phantastic Travels of Adelbert von Chamisso, SciHi Blog
-  Friedrich Wilhelm Bessel and the Distances of Stars, SciHi Blog
-  Robert Wilhelm Bunsen and the Bunsen Burner, SciHi Blog
-  Adolf von Baeyer at Wikidata
-  Timeline of Adolf von Baeyer via Wikidata