William Withering and the Clinical Value of Digitalis

William Withering

William Withering (1741-1799)

On March 17, 1741English botanist, geologist, chemist, physician William Withering was born. From his interest in botany, he paid attention to folk remedies used by herb-gatherers, and discovered digitalis, a very useful drug used to steady and strengthen heart action.

William Withering’s career choice was first highly influenced by his father, an apothecary and his uncle, a physicianWithering began his studies at the University of Edinburgh in 1762 which included a large medical curriculum as well. Withering was back then not interested in botany too much and he wrote his thesis on malignant sore throat, titled De Angina GangraenosaWithering later moved to Stafford where he also attended private patients and served as a founding physician of the Stafford General Infirmary.

It is believed that in Stafford, Withering started to enjoy botany. Further he met his  wife, Helena Cookes, who sketched the plants he collected. Seeking a better income, Withering and his family moved to Birmingham in order to fill a position after the death of physician and Lunar Society cofounder William Small in 1775. The so called Lunar Society was a gathering of naturalists and inventors who frequently met to travel under the light of the full moon. In Birmingham William Withering began to work together with the fellow physician John Ash, and Withering also served as a founder of the Birmingham General Hospital.

Digitalis purpurea drawings by Franz Köhler

Digitalis purpurea drawings by Franz Köhler

However, William Withering is probably best known for his 1785 publication An Account of the Foxglove, and Some of Its Medical Uses. Indeed foxglove, or Digitalis purpurea, had already been in use in folk medicine for several centuries. It is believed that Withering first learned of the use of Digitalis in treating “dropsy” from Mother Hutton, an old woman who practiced as a folk herbalist in Shropshire, who used the plant as part of a polyherbal formulation containing over 20 different ingredients to successfully treat this condition. Withering however intended to objectively demonstrate its efficiency in treating dropsy, the edematous bodily swelling that typically accompanied heart failure. Over the course of nine yearsWithering tried out different preparations of various parts of the plant and documented 156 cases where he had employed digitalis. He further described the best and safest ways of using it and he realized that foxglove’s action varied according to the plant’s stage of bloom.

Even though Erasmus Darwin initially supported Withering in starting the position at Birmingham, the two faced several conflicts concerning plagiarism during Withering’s career. For instance, Erasmus Darwin claimed priority in having published on foxglove’s therapeutic use in managing dropsy and one year prior, Darwin along with fellow members of the Lichfield Botanical Society, had published the first English translation of Swedish naturalist and explorer Carolus Linnaeus’ Genera et Species Plantarum without acknowledging Withering’s contributions.[4]

In his further career, William Withering also contributed to the clinical distinction of scarlet fever and to the medical use of lead and rum. In Portugal, he analyzed the mineral content of spa waters and prepared the English translation of Swedish chemist and naturalist Torbern Bergman’s mineralogy treatise in the 1780s. The flowering plant Witheringia solanacea (order Solanales) was named in his honour.

in 1783 Withering diagnosed himself as having pulmonary tuberculosis and went twice to Portugal hoping the better winter climate would improve his health; it did not. On the way home from his second trip there, the ship he was in was chased by pirates. In 1785 he was elected a Fellow of the prestigious Royal Society. He was also one of the members of the Lunar Society,  a dinner club and informal learned society of prominent figures in the Midlands Enlightenment, including industrialists, natural philosophers and intellectuals, who met regularly between 1765 and 1813 in Birmingham. During the Birmingham riots of 1791 he prepared to flee from his home in Edgbaston Hall, but his staff kept the rioters at bay until the military arrived. In 1799 he decided that he could not tolerate another winter in the cold and draughty Hall, so he bought “The Larches” in the nearby Sparkbrook area. However, it did not work out, William Withering died on 6 October 1799.

References and Further Reading:

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One comment

  • Mother Hutton never existed. She was ‘created’ in an illustration for a late 1920 advertising campaign by Parke-Davis. which showed Withering supposedly buying her secret recipe. Since then this fictitious woman has grown in reputation as authors copy each other and fail to go back to primary sources to check. Withering, the only primary source of this ‘secret recipe’ , mentions no-one by the name of Hutton – he is only asked to comment on a family recipe that was kept secret by an old woman.

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