Stanley Miller and the origins of Life

Stanley Miller (1930 - 2007)

Stanley Miller (1930 – 2007)

On March 7, 1930, American chemist Stanley Lloyd Miller was born. Miller made landmark experiments in the origin of life by demonstrating that a wide range of vital organic compounds can be synthesized by fairly simple chemical processes from inorganic substances. In 1952 he carried out the Miller–Urey experiment, which showed that complex organic molecules could be synthesised from inorganic precursors. The experiment was widely reported, and provided support for the idea that the chemical evolution of the early Earth had led to the natural synthesis of chemical building blocks of life from inanimate inorganic molecules.

Stanley Miller attended the University of California at Berkeley studying chemistry and graduated in 1951. Miller then registered for Berkeley’s PhD program and while searching for a decent research topic, Miller talked to many professors, and was initially convinced to work together with Edward Teller in theoretical physics. However, Miller later attended a lecture by Harold Urey who talked about the origin of solar system and how organic synthesis could be possible under reducing environment such as the primitive Earth’s atmosphere. This event sparked Stanley Miller’s enthusiasm for the topic. It is believed that Miller’s work with Teller was not as fruitful as hoped and due to the prospect of Teller leaving Chicago to work on the Hydrogen bomb, Miller approached Harold Urey in 1952 for a research project.

Even though Urey favored Stanley Miller to work on thallium in meteorites instead of pre-biotic synthesis, Miller persuaded Urey to pursue electric discharges in gases. As a result of their work, the famous Miller-Urey experiment was performed in 1952. The Miller-Urey chemical experiment simulated the conditions thought at the time to be present on the early Earth, and tested the chemical origin of life under those conditions. It confirmed Alexander Oparin’s and John Burdon Sanderson Haldane’s earlier hypothesis that putative conditions on the primitive Earth favoured chemical reactions that synthesized more complex organic compounds from simpler inorganic precursors.

In 1953, the Urey-Miller experiment appreared in Science and has become a textbook definition of the scientific basis of origin of life. The scientists designed to simulate the ocean-atmospheric condition of the primitive Earth by using a continuous run of steam into a mixture of methane, ammonia, and hydrogen. When the mixture was exposed to electrical discharge, a chemical reaction was induced. Miller was able to detect the formation of amino acids, such as glycine, α- and β-alanine, using paper chromatography. Miller further detected aspartic acid and gamma-amino butyric acid, however, was not so confident about these.

Stanley Miller received his doctorate in 1954 and continued his research until 2007. Throughout the years he improved the details and methods and was successful in synthesising more and more varieties of amino acids and producing a wide variety of inorganic and organic compounds essential for cellular construction and metabolism.

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