Camillo Golgi and the Golgi Apparatus

Camillo Golgi

Camillo Golgi

On July 7, 1843, Italian physician, pathologist, scientist, and Nobel laureate Camillo Golgi was born. His key discovery was the use of silver salts to stain samples for microscope slides. Thus new details of cellular structure components were revealed and several phenomena in anatomy and physiology are named for him, including the Golgi apparatus.

Camillo Golgi was born near Brescia in northern Italy. His father was a district medical officer. Golgi studied medicine at the University of Pavia under Giulio Bizzozero and Eusebio Oehl, and continued to work at the Hospital of St. Matteo in Pavia afterwards. It has been reported that Bizzozero had a great influence on Golgi in concerns of scientific research and especially in the fields of the nervous system, i.e. insanity, neurology and the lymphatics of the brain. At the Hospital for the Chronically Sick at Abbiategrasso, Golgi supposedly started his investigations into the nervous system in 1872. [1,2]

When Camillo Golgi returned to the University of Pavia as Chair for General Pathology in 1881, he succeeded his former teacher Bizzozero and married Bizzozero’s niece Donna Lina. During his time at the university, Golgi became an eager and liked teacher and it is said that his laboratory was always open to any student or scientist who wanted to work together or learn something. Golgi founded and directed the Istituto Sieroterapico-Vaccinogeno of the Province of Pavia and was Rector of Pavia University for a long time. During World War I, Golgi created a neuro-pathological and mechano-therapeutical centre for the study and treatment of peripheral nervous lesions and for the rehabilitation of the wounded. [1,2]

Camillo Golgi’s most famous achievement in science was probably his method of staining individual nerve and cell structures, which is referred to as the ‘black reaction‘. The method uses a solution of silver nitrate and is valuable in tracing the processes and most delicate ramifications of cells. It is not clear however, when Golgi made his discovery, but it is believed that he spent many years of his life modifying and improving the method. In 1898, Golgi also discovered and observed the Golgi Apparatus while investigating the nervous system. At first however, it is believed that Golgi doubted his discovery and argued that the structure was probably an optical illusion created by his observation technique. The term ‘Golgi Apparatus‘ first appeared in scientific literature in 1913. [1,3]

Camillo Golgi’s discovery marked a milestone in cell biology, even though the existence of the apparatus was debated for many years. In the 1950s, it was finally confirmed with the use of electron-microscopes [2]. In 1906 Golgi shared the Nobel Prize with Santiago Ramón y Cajal for their studies on the structure of the nervous system. Camillo Golgi died in January 1926. His publications are collected in the Opera Omnia, which appeared in 1903 and 1929; the latter was edited by his co-workers. [2]

At yovisto, you can learn more about the Golgi Apparatus in a short video lecture.

References and Further Reading:

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